PROSTAMATE® (dinoprost tromethamine injection) Sterile Solution INDICATIONS: For intramuscular use for estrus synchronization treatment of unobserved (silent) estrus and pyometra (chronic endometritis) in cattle; for abortion of feedlot and other non-lactating cattle; for parturition induction in swine; and for controlling the timing of estrus in estrous cycling mares and clinically anestrous mares that have a corpus luteum. DESCRIPTION This product contains the naturally occurring prostaglandin F2 alpha (dinoprost) as the tromethamine salt. Each mL contains dinoprost tromethamine equivalent to 5 mg dinoprost: also benzyl alcohol 9.45 mg added as preservative. When necessary pH was adjusted with sodium hydroxide and/or hydrochloric acid. Dinoprost tromethamine is a white or slightly off-white crystalline powder that is readily soluble in water at room temperature in concentrations to at least 200 mg/mL. General Biologic Activity: Prostaglandins occur in nearly all mammalian tissues. Prostaglandins especially PGE’s and PGF’s have been shown in certain species to 1) increase at time of parturition in amniotic fluid maternal placenta myometrium and blood 2) stimulate myometrial activity and 3) to induce either abortion or parturition. Prostaglandins especially PGF2α have been shown to 1) increase in the uterus and blood to levels similar to levels achieved by exogenous administration which elicited luteolysis 2) be capable of crossing from the uterine vein to the ovarian artery (sheep) 3) be related to IUD induced luteal regression (sheep) and 4) be capable of regressing the corpus luteum of most mammalian species studied to date. Prostaglandins have been reported to result in release of pituitary tropic hormones. Data suggest prostaglandins especially PGE’s and PGF’s may be involved in the process of ovulation and gamete transport. Also PGF2α have been reported to cause increase in blood pressure bronchoconstriction and smooth muscle stimulation in
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